Publications

• P. Srinivasan, C. T. Canova, S. Sha, T. N. T. Nguyen, J. Joseph, J. Sangerman, A. J. Maloney, G. Katsikis, R. W. Ou, M. S. Hong, J. Ng, A. Yuan, D. Antov, S. Song, W. Chen, C. Neufeld, J. M. Wolfrum, P. W. Barone, A. J. Sinskey, S. L. Springs, and R. D. Braatz. Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids. Biotechnology & Bioengineering, 2024.
• S. H. Kim, M. S. Hong, and R. D. Braatz. Investigation of particle flow effects in slug flow crystallization using the multiscale computational fluid dynamics simulation. Chemical Engineering Science, 297:120238, 2024.
• S. Byun, B. Ge, H. Song, S.-P. Cho, M. S. Hong, J. Im, and I. Chung. Simultaneously engineering electronic and phonon band structures for high-performance n-type polycrystalline SnSe. Joule, 8(5):1520-1538, 2024.
• F. Mohr*, M. S. Hong*, C. D. Castro, B. T. Smith, J. M. Wolfrum, S. L. Springs, A. J. Sinskey, R. A. Hart, T. Mistretta, and R. D. Braatz. Tensorial approaches combining timeseries and batch data for the end-to-end batch manufacturing of monoclonal antibodies. Computers & Chemical Engineering, 182:108557, 2024.
• J.Rhyu, D. Bozinovski, A. B. Dubs, N. Mohan, E. M. Cummings Bende, A. J. Maloney, M. Nieves, J. Sangerman, A. E. Lu, M. S. Hong, A. Artamonova, R. W. Ou, P. W. Barone, J. C. Leung, J. M. Wolfrum, A. J. Sinskey, S. L. Springs, and R. D. Braatz*. Automated outlier detection and estimation of missing data. Computers & Chemical Engineering, 179:108448, 2024.
• M. S. Hong*, F. Mohr*, C. D. Castro, B. T. Smith, J. M. Wolfrum, S. L. Springs, A. J. Sinskey, R. A. Hart, T. Mistretta, and R. D. Braatz. Smart process analytics for the end-to-end batch manufacturing of monoclonal antibodies. Computers & Chemical Engineering, 179:108445, 2023.
• P. Srisuma, A. Pandit, Q. Zhang, M. S. Hong, J. Gamekkanda, F. Fachin, N. Moore, D. Djordjevic, M. Schwaerzler, T. Oyetunde, W. Tang, A. Myerson, G. Barbastathis, and R. D. Braatz. Thermal imaging-based state estimation of a Stefan problem with application to cell thawing. Computers & Chemical Engineering, 173:108179, 2023.
• M. S. Hong, W. Sun, B. W. Anthony, and R. D. Braatz. Teaching process data analytics and machine learning at MIT. Chemical Engineering Education, 56(4):226-230, 2022.
• A. Nikolakopoulou*, M. S. Hong*, and R. D. Braatz. Dynamic state feedback controller and observer design for dynamic artificial neural network models. Automatica, 146:110622, 2022.
• P. R. Jeon, M. S. Hong, and R. D. Braatz. Compact neural network modeling of nonlinear dynamical systems via the standard nonlinear operator form. Computers & Chemical Engineering, 159:107674, 2022.
• M. S. Hong, A. E. Lu, J. Bae, J. M. Lee, and R. D. Braatz. Droplet-based evaporative system for the estimation of protein crystallization kinetics. Crystal Growth & Design, 21(11):6064-6075, 2021.
• N. J. Mozdzierz, M. S. Hong, Y. Lee, M. H. P. Benisch, M. Jiang, A. S. Myerson, and R. D. Braatz. Tunable protein crystal size distribution via continuous slug-flow crystallization with spatially varying temperature. CrystEngComm, 23(37):6495-6505, 2021.
• M. S. Hong*, A. E. Lu*, R. W. Ou, J. M. Wolfrum, S. L. Springs, A. J. Sinskey, and R. D. Braatz. Model-based control for column-based continuous viral inactivation of biopharmaceuticals. Biotechnology & Bioengineering, 118(8):3215-3224, 2021.
• N. J. Mozdzierz*, Y. Lee*, M. S. Hong*, M. H. P. Benisch, M. L. Rasche, U. E. Tropp, M. Jiang, A. S. Myerson, and R. D. Braatz. Mathematical modeling and experimental validation of continuous slug-flow tubular crystallization with ultrasonication-induced nucleation and spatially varying temperature. Chemical Engineering Research and Design, 169:275-287, 2021.
• T. N. T. Nguyen, S. Sha, M. S. Hong, A. J. Maloney, P. W. Barone, C. Neufeld, J. Wolfrum, S. L. Springs, A. J. Sinskey, and R. D. Braatz. Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells. Molecular Therapy — Methods & Clinical Development, 21:642-655, 2021.
• M. S. Hong, K. Kaur, N. Sawant, S. B. Joshi, D. B. Volkin, and R. D. Braatz. Crystallization of a nonreplicating rotavirus vaccine candidate. Biotechnology & Bioengineering, 118(4):1750-1756, 2021.
• M. S. Hong and R. D. Braatz. Mechanistic modeling and parameter-adaptive nonlinear model predictive control of a microbioreactor. Computers & Chemical Engineering, 147:107255, 2021.
• M. S. Hong, M. L. Velez-Suberbie, A. J. Maloney, A. Biedermann, K. R. Love, J. C. Love, T. K. Mukhopadhyay, and R. D. Braatz. Macroscopic modeling of bioreactors for recombinant protein producing Pichia pastoris in defined medium. Biotechnology & Bioengineering, 118(3):1199-1212, 2021.
• A. L. Gimpel, G. Katsikis, S. Sha, A. J. Maloney, M. S. Hong, T. N. T. Nguyen, J. Wolfrum, S. L. Springs, A. J. Sinskey, S. R. Manalis, P. W. Barone, and R. D. Braatz. Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies. Molecular Therapy — Methods & Clinical Development, 20:740-754, 2021.
• M. S. Hong, W. Sun, A. E. Lu, and R. D. Braatz. Process analytical technology and digital biomanufacturing of monoclonal antibodies. American Pharmaceutical Review, 23(6):122-125, 2020.
• M. S. Hong, K. A. Severson, M. Jiang, A. E. Lu, J. C. Love, and R. D. Braatz. Challenges and opportunities of biopharmaceutical manufacturing control. Computers & Chemical Engineering, 110:106-114, 2018.
• G. Tian, S. L. Lee, X. Yang, M. S. Hong, Z. Gu, S. Li, R. Fisher, and T. F. O'Connor. A dimensionless analysis of residence time distributions for continuous powder mixing. Powder Technology, 315:332-338, 2017.